Amsterdam Criteria

1. At least three relatives with histologically verified CRC;
   • one of the relatives should be a first degree relative to the other two.
   • Familial adenomatous polyposis should be excluded.
2. At least two successive generations should be affected.
3. In one of the relatives CRC should be diagnosed under 50 years of age.

International Collaborative Group on HNPCC (1990)